* Shire rises after Takeda approves takeover deal (Adds closing prices, details): LONDON (Reuters) - Worries about U.S. bond markets signaling an impending recession, and a still rumbling trade war between the world’s top two economies, saw European shares sink further on Wednesday after a 3 percent drop on Wall Street the previous day. The pan-European STOXX 600 ended down 1.2 percent at its lowest level since Nov. 23. The euro zone .STOXXE stock index and Germany's DAX .GDAXI also fell 1.2 percent.